Probable adverse interaction between oral metoprolol and verapamil.
نویسندگان
چکیده
A combination of an oral beta-adrenergic blocking agent and verapamil has been advocated as a safe treatment for angina. A case of Wenckebach type atrioventricular block occurring in a patient on metoprolol and verapamil is reported. It is suggested that this combination is used with caution.
منابع مشابه
Slow Calcium Channel Blockade in Man
The administration of verapamil to patients receiving ,B-adrenergic blocking drugs is reported to produce adverse circulatory reactions, but a systematic investigation of this potential drug interaction has not been performed in man. We administered 40-, 80and 120-mg doses of verapamil orally to 15 patients with angina pectoris who were receiving high doses of propranolol or metoprolol. Verapam...
متن کاملTreating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol.
STUDY OBJECTIVE To compare responses of blood pressure to the calcium antagonist verapamil and the beta blocker metoprolol in black compared with white diabetics with hypertension and to monitor urinary albumin excretion in relation to fall in blood pressure. DESIGN Double blind, placebo controlled, random order crossover trial with four week placebo run in period and two six week active phas...
متن کاملHemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man.
The administration of verapamil to patients receiving beta-adrenergic blocking drugs is reported to produce adverse circulatory reactions, but a systematic investigation of this potential drug interaction has not been performed in man. We administered 40-, 80- and 120-mg doses of verapamil orally to 15 patients with angina pectoris who were receiving high doses of propranolol or metoprolol. Ver...
متن کاملEffects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS)
OBJECTIVE To study long-term treatment effects of metoprolol or verapamil on combined cardiovascular end points and psychological variables in patients with stable angina pectoris. DESIGN Randomized, double-blind, double-dummy trial. PATIENTS The study included 809 patients under 70 years of age with stable angina pectoris. The mean age of the patients was 59 +/- 7 years and 31% were women....
متن کاملThe effects of chronic oral administration of verapamil on thyroid function in rat
Introduction: Verapamil, a phenylalkylamin –type Ca2+ channel blocker, is widely used in the treatment of cardiovascular disorders especially as an antiaryhthmic and antiangina agent. Theoretically, calcium can influence thyroid function and there are evidences that Ca2+ channel blockers are able to interfere with thyroid function. In this study, the effects of chronic oral administration of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Postgraduate medical journal
دوره 60 708 شماره
صفحات -
تاریخ انتشار 1984